This book constitutes the refereed proceedings of the 28th International Workshop on Computer Algebra in Scientific Computing, CASC 2026, held in Bath, UK, during August 31–September 4, 2026.

The 21 full papers included in this book were carefully reviewed and selected from 28 submissions. The CASC workshop series has been running for over two decades to explore the interaction of Computer Algebra Systems and the underlying algorithms for Symbolic Computation, as well as their implementation, and their application.