This book constitutes the refereed proceedings of the 22nd International Conference on Mobile Web and Intelligent Information Systems, MobiWIS 2026, held in Granada, Spain, during July 20–22, 2026.

The 27 full papers and 2 short papers included in this book were carefully reviewed and selected from 88 submissions. They were organized in topical sections as follows: RAG and GenAI; Security, Privacy and Trust I; Security, Privacy and Trust II; Web Services and Applications; Mobile Healthcare Applications; AI-based Systems; E-Commerce Systems; and Network Models and Protocols.