This two-set volume CCIS 3103-3104 constitutes the proceedings of the 17th International Conference on Management of Digital EcoSystems, MEDES 2025, held in Ho Chi Minh City, Vietnam, during November 24–26, 2025.

The 46 full papers and 12 short papers included in these volumes were carefully reviewed and selected from 96 submissions. They are organized into topical sections as follows: 

Part I: Education and Learning; Deep Learning; Smart Cities; Parallel and Distributed Architectures; Modeling and Ontologies; AI Theoretical Issues; Health and Medical Issues; Theoretical Issues; AI Technical Issues; and Applications.

Part II: Workshop: AI-SBKE,Workshop: DEPRWorld,Workshop: AI-Driven MultiGIS and Student Track.