This book presents selected, peer-reviewed contributions from the 7th Mediterranean Conference on Pattern Recognition and Artificial Intelligence (MedPRAI-26), showcasing recent advances and emerging directions in artificial intelligence, machine learning, and data-driven technologies across a wide range of applications. This book covers both methodological developments and practical implementations, including deep learning, computer vision, natural language processing, and optimization techniques, alongside applications in healthcare (e.g., disease detection, medical imaging, and clinical prediction), cybersecurity and blockchain, intelligent transportation, energy systems, and industrial processes. In addition to technical innovations, several contributions address ethical considerations, responsible AI, and sustainability, reflecting the growing importance of trustworthy and socially aware intelligent systems.