This comprehensive book provides an overview of Primary Ovarian Insufficiency (POI) and early menopause, reflecting the advances made in reproductive aging, hormone therapy, and clinical management. While consensus guidelines, terminology, and treatment options have evolved substantially, important gaps remain in understanding the underlying causes of POI and in preparing healthcare professionals to identify, prevent, and manage the condition effectively.

The text begins by examining the continuum of reproductive aging, clarifying the concepts of ovarian reserve, early menopause, and the terminology surrounding premature and primary ovarian insufficiency. It then explores the causes of POI, including genetic factors, autoimmune disorders, environmental and lifestyle influences, and treatment-related or iatrogenic contributors. The text contains insight into the psychological impact of diagnosis, as well as the metabolic, skeletal, neurocognitive, and cardiovascular risks associated with prolonged hypoestrogenism and accelerated reproductive aging. These chapters emphasize the importance of early recognition and long-term health surveillance. The management portion of the book focuses on evidence-based strategies to support individuals living with POI. Key topics include fertility options, symptom management for estrogen deficiency, and the role of hormone therapy in reducing the risk of chronic age-related conditions and preserving overall health and quality of life. Finally, the book highlights emerging preventive and pre-emptive considerations. Chapters on stem cell-based and regenerative therapies review their biological rationale, current evidence, and translational challenges, while discussions of oocyte and ovarian tissue cryopreservation examine established fertility-preservation strategies.

Designed for women’s health providers, including physicians, trainees, nurses, midwives, advanced practice clinicians, and specialists across obstetrics and gynecology, endocrinology, family medicine, pediatrics, psychiatry, and internal medicine, Early Menopause and Primary Ovarian Insufficiency: Diagnosis and Management aims to strengthen clinical preparedness and improve outcomes for individuals affected by POI.

Amanda N. Kallen
Department of Obstetrics
Gynecology and Reproductive Sciences,
University of Vermont
Burlington VT
USA 

Pinar H. Kodaman
Tennessee Fertility Institute Nashville, TN USA

Lubna Pal

Division of Reproductive Endocrinology & Infertility

Department of Obstetrics, Gynecology & Reproductive Sciences

Yale School of Medicine, New Haven, CT, USA.