Bringing together the full spectrum of contemporary epilepsy surgery, this authoritative volume provides a practical, evidence-based guide to the evaluation and surgical management of patients with medically refractory epilepsy. Leading experts walk readers through every stage of the surgical pathway, from preoperative workup and advanced imaging to neuropsychological assessment, invasive monitoring, and patient selection. Comprehensive coverage of specialized topics—including MR imaging, PET, SPECT, MEG, stereoelectroencephalography (SEEG), subdural grid implantation, pediatric considerations, and perioperative anesthesia—equips clinicians with the knowledge needed to make informed decisions in complex cases.

The book offers detailed, technique-focused guidance on both traditional and emerging surgical interventions. Dedicated chapters examine the principles, anatomy, and operative strategies for temporal, frontal, insular, parietal, occipital, cingulate, and central region epilepsy, as well as focal cortical dysplasia, epileptogenic tumors, hemispherectomy, multilobar resections, and corpus callosotomy. Surgical adjuncts such as awake craniotomy, electrocorticography, and functional mapping are presented alongside practical insights that help optimize safety, precision, and patient outcomes.

Expanding beyond open surgery, the text explores the rapidly evolving field of minimally invasive and neuromodulatory therapies, including laser interstitial thermal therapy (LITT), SEEG-guided radiofrequency thermocoagulation, vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation. The volume concludes with thoughtful discussions of ethics, quality of life, complications, reoperations, and neuropathology, providing a holistic view of epilepsy surgery in modern practice. Essential for neurosurgeons, epileptologists, neurologists, neuroradiologists, neuropsychologists, and trainees, this book serves as a comprehensive resource for advancing surgical care for patients with epilepsy.

Demitre Serletis, MD, PhD, Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA

Dr. Demitre Serletis is an epilepsy neurosurgeon-scientist in the Cleveland Clinic Epilepsy Center, whose surgical practice focuses on adult and pediatric patients with epilepsy. He also directs the Brain Dynamics Laboratory, with research interests in nonlinear dynamics, neuroengineering and machine learning, and he holds a joint appointment with the Department of Biomedical Engineering in the Cleveland Clinic Lerner Research Institute. Dr. Serletis is a graduate of the University of Toronto in Canada, where he completed his Neurosurgery Residency and PhD graduate training in Neuroengineering. He subsequently completed formal Epilepsy Surgery Fellowship training at the Cleveland Clinic, and he has previously worked at the University of Arkansas for Medical Sciences (Little Rock) and the University of Manitoba (Winnipeg, Canada).  

Richard Rammo, MD, Center for Neurological Restoration, Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA

Dr. Richard Rammo is a functional/epilepsy neurosurgeon at the Cleveland Clinic. He treats patients within the Center for Neurological Restoration and the Epilepsy Center and has clinical interests in resective and neuromodulatory approaches to epilepsy. Dr. Rammo is a graduate of the Neurological Surgery Residency Program at Henry Ford Hospital in Detroit, and has completed fellowships in Stereotactic and Functional Neurosurgery, as well as Epilepsy Neurosurgery, at the Cleveland Clinic.

William E. Bingaman, MD, Department of Neurological Surgery, Case Western Reserve University, Neurological Institute, Epilepsy Center, Cleveland Clinic, Cleveland, OH, USA

Dr. William E. Bingaman is a Professor of Neurological Surgery in the Lerner College of Medicine of Case Western Reserve University, and serves as the Vice-Chairman of the Neurological Institute and Head of the Section of Epilepsy Surgery at Cleveland Clinic. His clinical interests are in the surgical treatment of adult and pediatric epilepsy, with special interests and expertise in hemispheric epilepsy. Dr. Bingaman is a graduate from Temple University Medical School in Philadelphia, and from the Cleveland Clinic Neurosurgery Residency Program. He has also completed fellowship training in Spinal Neurosurgery at the Cleveland Clinic, where he has served as faculty since 1997.