This book showcases the state of the art in the field of sensors and microsystems, revealing the impressive potential of novel methodologies and technologies. It covers a broad range of aspects, including: bio-, physical and chemical sensors; actuators; micro- and nano-structured materials; mechanisms of interaction and signal transduction; polymers and biomaterials; sensor electronics and instrumentation; analytical microsystems, recognition systems and signal analysis; and sensor networks, as well as manufacturing technologies, environmental, food and biomedical applications. This book gathers a selection of papers presented at the XXIV AISEM National Conference on Sensors and Microsystems, held in Catania, Italy, in February 2026, which brought together researchers, end users, technology teams and policymakers.