This book constitutes the refereed post proceedings of the 5th International Scientific and Practical Conference on Information Technologies and Intelligent Decision Making Systems, ITIDMS 2025, held in Margilan, Uzbekistan, during December, 11-13, 2025.

The 17 full papers included in this book were carefully reviewed and selected from 49 submissions. They focus on topics such as digital, intellectual and information transformation, the development of computer models and the improvement of automated and computing processes.