A unique and attractive feature of this book is the updated, integrated and extended data presented on both basic and practical aspects related to the understudied field of the tumor microenvironment.

Since the 1e (2017), several of these topics and areas have been significantly advanced, in particular the field of tumor immunology and immunotherapy, which relates to a key component in the tumor microenvironment.

The number of chapters was increased from 21 to 34 in the 1e and 2e, and the 3e will have a further  8 new chapters, in addition to updated versions of the 34 chapters from the 2e.

The 3e will have an epilogue added by Prof. Marta Bertolaso (Rome), with a draft title “Philosophy of cancer complexity”.

Research pathologists and basic researchers using novel morphology techniques will find this a useful read. In addition this book is suitable for teaching and course programs in research schools focusing on basic concepts and translational cancer research.

Additional benefits:

• provides the reader with an integrated and updated review of contemporary biology and biomarker research in the field of the tumor microenvironment
• contains a large number of high-quality illustrations and color images of tissue-based biomarkers
• tables with summaries of current knowledge with key references, and text boxes with bullet points, are included
• written by a team of international authors and opinion leaders in different research fields
• structured in a number of sections ranging from basic model studies of novel biomarkers and potential therapeutic targets in the microenvironment, exploration and validation of different classes of biomarkers in human tumors, to the challenges of clinical implementation and trials
• the book is relevant to basic researchers using morphology techniques and research pathologists

Lars A. Akslen is a professor of medicine (tumor pathology) at the University of Bergen (Bergen, Norway), a senior consultant in surgical pathology at Haukeland University Hospital, a director of the Centre for Cancer Biomarkers CCBIO, a Norwegian Center of Excellence, and a foreign adjunct professor of pathology at Karolinska Institutet (Stockholm, Sweden). Dr. Akslen is working on biomarkers of the tumor microenvironment and how these can be defined and reported on tissue specimens from human cancers, in particular breast tumors. Areas of interest: angiogenesis, immune responses, breast cancer proteomics, cancer neuroscience.

Randolph S. Watnick is a trained molecular biologist and is currently a research associate at the Vascular Biology Program, Boston Children´s Hospital (Boston, USA), and an assistant professor at the Department of Surgery, Harvard Medical School. After receiving his Ph.D., Dr. Watnick continued his training as a post-doctoral fellow in the laboratory of Dr. Robert Weinberg at the Whitehead Institute for Biomedical Research. Dr. Watnick is now working on mechanisms of how the tumor microenvironment promotes cancer progression, with particular focus on roles of the immune system and vascular structures.