Towards a Regenerative, Holistic, and Intelligent Bioeconomy presents a paradigm shift from linear, extractive economic models toward a regenerative, data-enabled, and life-centered bioeconomy in Latin America and the Caribbean. Moving beyond conventional sustainability frameworks focused on fossil substitution, the volume advances “regeneration by design,” positioning ecosystem restoration, biocultural diversity, and planetary health as central economic drivers.

Bringing together leading scholars and practitioners, this edited collection introduces the Jach’a Qh’anax model, an innovative integrative framework that bridges Artificial Intelligence, Digital Twins, and advanced computational systems with Indigenous and ancestral ecological knowledge. This book explores how Bioeconomy 4.0 can be operationalized through circular biotechnology, smart agrosystems, and decentralized governance architectures, while addressing key challenges such as digital extractivism, data sovereignty, and territorial inequality.

Through interdisciplinary perspectives spanning agroecology, economics, biotechnology, and environmental governance, the chapters combine theoretical foundations with applied case studies, including bio-based pest control, forest bioeconomy systems, hydro-governance, ethnomedicine, and circular aquaculture.

Designed for researchers, graduate students, policymakers, and innovation leaders, this volume provides actionable frameworks aligned with the Sustainable Development Goals, offering a roadmap toward equitable, resilient, and regenerative economies. Towards a Regenerative, Holistic, and Intelligent Bioeconomyis is an essential resource for advancing the convergence of AI, biocultural systems, and sustainable development in the Global South.