This book provides a comprehensive overview of circadian rhythms, from their molecular mechanisms to their emerging applications in precision medicine. Bringing together contributions from leading scientists across the different areas of circadian research and medicine, it explores how the biological clock regulates human physiology and how understanding, measuring and modelling circadian rhythms can be translated into strategies to improve health, disease prevention, diagnosis and treatment.

The first part presents the molecular mechanisms underlying circadian rhythms and their interactions with other physiological systems, including the endocrine system. It introduces experimental approaches for assessing circadian rhythms as well as computational and mathematical methods for analysing and interpreting circadian data.

The second part focuses on translational applications in human health, including personalized chronotherapy and diagnostics, sleep, women’s health and ageing. The third part examines the role of circadian disruption in disease and explores how circadian biology, computational modelling and pharmacology can be integrated to optimize the timing of therapeutic interventions, with applications in cancer, neurodegenerative diseases and space medicine.

As circadian biology increasingly moves from fundamental research toward clinical translation, the book highlights the opportunities and challenges involved in integrating biological timing into personalized medicine. By bringing together fundamental biology, quantitative approaches and clinical translation, this volume provides researchers, clinicians and students with an interdisciplinary perspective on the rapidly developing field of circadian medicine and illustrates how understanding biological time can contribute to more personalized approaches to health, disease prevention and treatment.

Prof. Dr. Angela Relógio is a German-Portuguese physicist-engineer and molecular biologist and Professor of Systems Medicine at MSH Medical School Hamburg, where she leads research in circadian medicine and systems biology. Her interdisciplinary research combines molecular and systems biology, mathematical modelling and data-driven approaches to investigate the human circadian clock and its role in health and disease, with a particular focus on cancer and chronotherapy.

She is founder and CEO of TimeTeller GmbH, an award winning spin-off from Charité – Universitätsmedizin Berlin developing molecular and AI-based approaches to assess individual circadian rhythms and translate biological timing into personalized health and therapeutic strategies. Her work bridges fundamental circadian biology, technology development and clinical translation. Angela Relógio is also the author of Die Chrono-Strategie and has received several awards for her scientific and entrepreneurial work.