This conference volume constitutes the proceedings of the 4th Eurasian Conference, HCI-E 2025, held at Azerbaijan State University of Economics (UNEC), Baku, Azerbaijan, during December 5–6, 2025.

The 30 full papers were included in this were carefully reviewed and selected from 82 submissions. They focus on Communication hardware, Mathematical software, Artificial intelligence, Machine learning, Modeling and simulation, Database and storage security, Systems security.