This book constitutes the refereed proceedings of the First International Conference on Quantum Computing Infrastructure and Technologies, QUANCOM 2026, held in Trento, Italy, during September 1–4, 2026.

The 30 full papers and 2 short papers included in this book were carefully reviewed and selected from 68 submissions. They are organized into the following topical sections: Quantum Machine Learning & Hybrid AI Applications; Quantum Optimization, Algorithms & Scientific Computing; and Quantum Systems, Software, Error Mitigation & Tooling.