This book aims serves as a practical resource for the Clinical Immunologist in the era of genetic/genomic revolution. It is increasingly relevant for physicians to understand genetic defects that drive disease. The knowledge of the specific genetically-defined underlying immunodeficiency allow for definitive diagnosis, prognostication, targeted therapy, including the use of biologicals and gene therapy, and family counselling.

Practical, and including a wealth of clinical cases to provide additional teaching tools, this book provides a thorough grounding of genetics for the immunologist. An introduction to types of genetic defects in PID offers readers a base knowledge, and later chapters cover topics like testing platforms, how to choose the best genetic test, how to interpret findings and how to explain and communicate this information to patients.

Concise and easy-to-use, this much-needed book will provide an excellent resource for immunologists in a fast-moving new field.

Jolan Walter MD PhD FAAAAI Associate Professor University of South Florida at Johns Hopkins All Children’s Hospital St Petersburg FL

Emily S.J. Edwards, PhD Group Leader, Primary Immunodeficiencies Group Department of Immunology School of Translational Medicine Monash University Melbourne Australia

Attila Kumanovics, MD Director, Cellular and Molecular Immunology Laboratory Department of Laboratory Medicine and Pathology Mayo Clinic, Rochester, Minnesota, USA