This comprehensive book provides an interdisciplinary overview of the endocannabinoid system (ECS), integrating its molecular foundations, physiological functions, pharmacology, and clinical relevance. It traces the development of cannabinoid science from its historical origins and pioneering discoveries to current advances in endocannabinoid research and cannabinoid-based medicine. It examines key components and mechanisms of the ECS, including cannabinoid receptors, endogenous ligands, retrograde signaling, and the endocannabinoidome. It also explores the cannabis plant, phytocannabinoids, synthetic cannabinoids, routes of administration, drug interactions, adverse effects, contraindications, nanotechnology, precision medicine, and deprescribing.

Dedicated chapters explore the role of the ECS across major physiological systems, including the nervous, cardiovascular, digestive, endocrine, immune, musculoskeletal, reproductive, respiratory, and integumentary systems. Its relationships with nutrition and physical activity are also addressed. Further chapters discuss cannabinoid applications in dentistry, ethical and legal considerations, international regulatory perspectives, and the distinction between phytopharmaceuticals and phytocomplexes.

Bridging fundamental science and clinical practice, this book provides physicians, researchers, healthcare professionals, and students with a comprehensive reference for understanding the endocannabinoid system and the evolving field of cannabinoid medicine.

Dr. José Wilson Andrade is a highly accomplished orthopedic surgeon and endocannabinology expert with over two decades of experience in medical practice and research. He graduated in Medicine from the prestigious Faculty of Medicine at the University of São Paulo (USP) in 1997. Completed his residency in Orthopedics and Traumatology at the Institute of Orthopedics and Traumatology, Hospital das Clínicas, Faculty of Medicine, USP (IOT-HCFMUSP), where he further specialized in hip surgery and pathology. With a decade of dedicated experience in endocannabinology, has emerged as a leading figure in the field of medicinal cannabis. He serves as the President of the Pan-American Multidisciplinary Association of Endocannabinoidology and is a member of the Deliberative Council of the Parliamentary Front for Medicinal Cannabis at the São Paulo State Legislative Assembly. His extensive clinical and research expertise in orthopedics, hip pathology, and cannabinoid-based therapies uniquely positions him to contribute to innovative research proposals in these domains.