Birkhäuser Advances in Infectious Diseases: A New Generation

Dormitzer, Philip R.; Mandl, Christian W.; Rappuoli, Rino

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

Details

Published by: Springer

Publication Date: 2013-01-02

Format: Paperback

ISBN-13: 9783034803168

DOI: 10.1007/978-3-0346-0277-8

Dimensions: 235cm x155cm

Pages: 447