{"product_id":"9783319003023","title":"SpringerBriefs in Molecular Science: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development","description":"\u003ch1\u003eSpringerBriefs in Molecular Science: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development\u003c\/h1\u003e \u003ch2\u003eByers, B. Rowe\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eIron Acquisition by the Genus \u003ci\u003eMycobacterium\u003c\/i\u003e summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by \u003ci\u003eM. tuberculosis\u003c\/i\u003e is featured. Because new drugs for \u003ci\u003eM. tuberculosis\u003c\/i\u003e are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and\/or conjugates.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-06-03\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319003023\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-00303-0\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 92\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":47400990605452,"sku":"9783319003023","price":49.49,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319003023.jpg?v=1775788057","url":"https:\/\/lateknightbooks.com\/products\/9783319003023","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}