{"product_id":"9783319307039","title":"Redox-Active Therapeutics","description":"\u003ch3\u003eOxidative Stress in Applied Basic Research and Clinical Practice\u003c\/h3\u003e\u003ch1\u003eRedox-Active Therapeutics\u003c\/h1\u003e\u003ch3\u003eInes Batinić-Haberle | Júlio S. Rebouças | Ivan Spasojević\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eScience \/ Life Sciences \/ Cell Biology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eThis essential\r\nvolume comprehensively discusses redox-active therapeutics, focusing\r\nparticularly on their molecular design, mechanistic, pharmacological and\r\nmedicinal aspects.  The first section of the book describes the basic\r\naspects of the chemistry and biology of redox-active drugs and includes a brief\r\noverview of the redox-based pathways involved in cancer and the medical aspects\r\nof redox-active drugs, assuming little in the way of prior knowledge.\r\nSubsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative\r\ndiseases, pain, radiation injury and radioprotection (such as of brain, lungs, head\r\nand neck and erectile function) and neglected diseases (e.g., leishmaniasis).\r\nIt encompasses several major classes of redox-active experimental therapeutics, which\r\ninclude porphyrins, salens, nitrones, and most notably metal-containing (e.g.,\r\nMn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with\r\nnanomaterials and quantum dots. Numerous illustrations, tables\r\nand figures enhance and complement the text; extensive references to relevant\r\nliterature are also included.\u003c\/p\u003e\n\u003cp\u003e \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eRedox-Active Therapeutics \u003c\/i\u003eis an invaluable addition to Springer’s \u003ci\u003eOxidative\r\nStress in Applied Basic Research and Clinical Practice\u003c\/i\u003e  series.\r\n It is essential reading for researchers, clinicians and graduate students\r\ninterested in understanding and exploring the Redoxome—the organism redox\r\nnetwork—as an emerging frontier in drug design, redox biology and medicine.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eINES BATINIC-HABERLE,\r\nPhD\u003c\/b\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003eInes Batinic-Haberle is a Professor of Radiation\r\nOncology at the Department of Radiation Oncology, Duke University School of\r\nMedicine. She received her B.Sc. in Food Chemistry, M.Sc. degree in Analytical\r\nChemistry, and her Ph.D. degree in Bioinorganic Chemistry from the School of\r\nPharmacy and Biochemistry, University of Zagreb, Croatia. She completed her\r\npostdoctoral education at the Department of Chemistry, Duke University. She then\r\nmoved to the Department of Biochemistry at Duke University School of Medicine,\r\nwhere she was trained by Irwin Fridovich, the Father of the field of\u003ci\u003e Free Radicals in Biology and Medicine. \u003c\/i\u003eShe\r\nspent 10 years in Fridovich’s Lab where she acquired the basis of her expertise\r\nin \u003ci\u003eOxidative Stress\u003c\/i\u003e and \u003ci\u003eRedox-Active Therapeutics\u003c\/i\u003e and launched\r\nthe design of powerful Mn porphyrin-based SOD mimics.  She established the structure-activity\r\nrelationship for Mn porphyrin-based SOD mimics, which she subsequently extended\r\nto all classes of SOD mimics. She holds a number of compositional and methods\r\nof use patents on metalloporphyrins; her lead compounds are either already in\r\nor entering Clinical Trials in 2016. She authored more than 190 manuscripts,\r\nseveral book chapters, has served as Guest\/Invited Editor and reviewer of\r\nvarious prestigious journals and granting agencies both nationally and internationally.\r\nFor the last 6 years she has served as a \u003ci\u003eSociety\r\nfor Redox Biology and Medicine\u003c\/i\u003e (SFRBM) Officer and is a founding member of\r\nthe \u003ci\u003eSociety of Porphyrins and\r\nPhthalocyanines\u003c\/i\u003e. She was recently awarded the SFRBM Excellence in Mentoring\r\nAward. She has organized numerous Symposia nationally and internationally and\r\ngave lectures at numerous Universities in the USA and abroad. She has\r\nestablished numerous collaborations with research groups in USA and\r\ninternationally and worked actively in advancing metalloporphyrins towards\r\nclinic.\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cb\u003eJULIO S. REBOUCAS, PhD\u003c\/b\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003eJulio\r\nS. Reboucas is an Adjunct Professor at Universidade Federal da Paraiba (UFPB,\r\nBrazil), Adjunct Head of the UFPB Chemistry Graduate Programs, and Fellow of\r\nthe Brazilian National Research Council (CNPq). He received his Chemical\r\nEngineering B.Sc. and Chemistry M.Sc. degrees from Universidade Federal de Minas\r\nGerais (Brazil) and his Chemistry Ph.D. degree from the University of British\r\nColumbia (Canada). He joined the Batinic-Haberle and Spasojevic Laboratories at\r\nDuke University (USA) in 2006, where he completed his postdoctoral training in oxidative\r\nstress and porphyrin-based redox-active therapeutics, before moving to UFPB in\r\n2009 to establish an accredited porphyrin research group. His research spans\r\nthe fields of medicinal and inorganic chemistry, with emphasis on\r\nporphyrin-based biomimetic systems. He has co-authored 52 manuscripts, two book\r\nchapters, and has one patent application. He is a founding member of the \u003ci\u003eSociety of Porphyrins and Phthalocyanines\u003c\/i\u003e\r\nand currentlyserves as the elected Inorganic Chemistry Division secretary of\r\nthe \u003ci\u003eBrazilian Chemical Society\u003c\/i\u003e. Among\r\nhis honors and awards is receiving the Young Investigator Award by the \u003ci\u003eSociety for Redox Biology and Medicine\u003c\/i\u003e. He\r\nhas collaborated with various groups within Brazil and abroad on porphyrin\r\nchemistry and medicine.\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cb\u003eIVAN SPASOJEVIC, PhD\u003c\/b\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003eIvan Spasojevic\r\nis an Assistant Professor of Medicine at the Department of Medicine, Division\r\nof Oncology. He is also a Director of the PK\/PD Core Lab of Duke Cancer\r\nInstitute Pharmaceutical Research Shared Resource, an NCI-supported\r\nstate-of-the-art bioanalytical facility providing study design and modeling\r\nexpertise in pharmacokinetics\/pharmacodynamics (PK\/PD) and performing analysis\r\nof drugs and their metabolites, oxidative stress markers and other small\r\nbiomolecules in general. His Lab has provided the invaluable support in the\r\ndevelopment of Mn porphyrins towards Clinical Trials. Ivan earned his B.Sc.\r\ndegree in Chemical Engineering from the School of Chemical Engineering, Zagreb,\r\nCroatia and his Ph.D. Degree in Bioinorganic Chemistry from the Department of\r\nChemistry, Duke University. He completed his postdoctoral training with Irwin\r\nFridovich in the field of \u003ci\u003eOxidative stress\u003c\/i\u003e and \u003ci\u003eFree Radicals in\r\nBiology and Medicine\u003c\/i\u003e and started his work on the design of Mn\r\nporphyrin-based SOD mimics. He has co-authored 126 manuscripts including\r\nseveral Book Chapters, has several compositional and method of use patents and\r\npatent applications. He has served as Guest\/Invited Editor and reviewer of\r\nvarious prestigious journals and was invited speaker\/organized symposia at National\r\nand International Meetings. He is a founding member of the \u003ci\u003eSociety of\r\nPorphyrins and Phthalocyanines\u003c\/i\u003e. He has collaborated with numerous groups in\r\nand outside of USA in the field of drug development and pharmacokinetics.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e24 October 2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer Nature Switzerland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783319307039\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e694\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":44398728904844,"sku":"9783319307039","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319307039.jpg?v=1780594651","url":"https:\/\/lateknightbooks.com\/products\/9783319307039","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}