{"product_id":"9783319666518","title":"Understanding the Gut-Bone Signaling Axis Mechanisms and Therapeutic Implications","description":"\u003ch3\u003eAdvances in Experimental Medicine and Biology\u003c\/h3\u003e\u003ch1\u003eUnderstanding the Gut-Bone Signaling Axis\u003c\/h1\u003e\u003ch2\u003eMechanisms and Therapeutic Implications\u003c\/h2\u003e\u003ch3\u003eLaura R. McCabe | Narayanan Parameswaran\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Endocrinology \u0026amp; Metabolism\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eThe first book  to combine current knowledge on gut and bone research\u003c\/p\u003e\n\u003cp\u003eAuthored by international experts in the field\u003c\/p\u003e\n\u003cp\u003eReviews exhaustively the key recent research regarding everything from signaling pathways to pathologies to intestinal environments\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e\n\u003cp\u003eLaura R. McCabe, PhD is the Director of the Molecular Metabolism and Disease Program at Michigan State University. Dr. McCabe’s research focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Her lab is taking an integrative approach to examine bone adaptation to diseases (such as diabetes and inflammatory bowel disease) and is working toward identifying mechanisms regulating bone formation by osteoblasts.  Approaches include examination of transcription factor activity, intracellular signaling pathway activation, stem cell lineage selection, apoptosis, metabolism and immune system contributions utilizing cell culture systems, animal models and human imaging. Dr. McCabe’s lab is also developing therapeutics to target identified mechanisms and pathways to increase bone formation.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e23 November 2017\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer Nature Switzerland\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783319666518\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e277\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer Nature Switzerland","offers":[{"title":"Default Title","offer_id":44398532788364,"sku":"9783319666518","price":161.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319666518.jpg?v=1780592696","url":"https:\/\/lateknightbooks.com\/products\/9783319666518","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}