{"product_id":"9783319798998","title":"Current Topics in Microbiology and Immunology","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology\u003c\/h1\u003e \u003ch2\u003eKurosaki, Tomohiro; Wienands, Jürgen\u003c\/h2\u003e \u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis\nvolume details our current understanding of the architecture and signaling\ncapabilities of the B cell antigen receptor (BCR) in health and disease. The\nfirst chapters review new insights into the assembly of BCR components and\ntheir organization on the cell surface. Subsequent contributions focus on the\nmolecular interactions that connect the BCR with major intracellular signaling\npathways such as Ca\u003csup\u003e2+\u003c\/sup\u003e mobilization, membrane phospholipid\nmetabolism, nuclear translocation of NF-kB or\nthe activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements\norchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics\nfor antigen internalization. Furthermore, a key mechanism of how B cells\nremember their cognate antigen is discussed in detail. Altogether, the discoveries\npresented provide a better understanding of B cell biology and help to explain\nsome B cell-mediated pathogenicities, like autoimmune phenomena or the\nformation of B cell tumors, whilealso paving the way for eventually combating these\ndiseases.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2018-03-30\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783319798998\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-319-26133-1\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 231\u003c\/p\u003e ","brand":"Springer International Publishing","offers":[{"title":"Default Title","offer_id":50089769861260,"sku":"9783319798998","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783319798998.jpg?v=1779503037","url":"https:\/\/lateknightbooks.com\/products\/9783319798998","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}