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Resistance to Targeted Anti-Cancer Therapeutics
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Resistance to Targeted Anti-Cancer Therapeutics
Donnadieu, Emmanuel
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.
The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
Details
Published by: Springer
Publication Date: 2018-04-22
Format: Paperback
ISBN-13: 9783319825281
DOI: 10.1007/978-3-319-42223-7
Dimensions: 235cm x155cm
Pages: 199