This volume provides a broad introduction in Natural Orifice Transluminal Endoscopic Surgery (NOTES) to the novice, as well as a comprehensive and up-to-date review of the major areas of research in this field for those already performing NOTES. Designed as stand-alone treatises on each particular topic, the chapters are arranged around management of esophageal motor disorders, gastric closure, transgastric NOTES, transvaginal procedures, transrectal NOTES and natural orifice colorectal surgery, and also novel natural orifice techniques that go beyond routine diagnostic and therapeutic endoscopy.