Bioisosteres in Medicinal Chemistry

Brown, Nathan; Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.

The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.

With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Details

Published by: Wiley-VCH

Publication Date: 2012-10-15

Format: Hardcover

ISBN-10: 9783527330157

ISBN-13: 9783527330157

DOI:

Dimensions: 246.40cm x174.00cm

Pages: 256