{"product_id":"9783527330157","title":"Bioisosteres in Medicinal Chemistry","description":"\u003ch1\u003eBioisosteres in Medicinal Chemistry\u003c\/h1\u003e \u003ch2\u003eBrown, Nathan; Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd\u003c\/h2\u003e \u003cp\u003eWritten with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.\u003cbr\u003e As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.\u003cbr\u003e \u003cbr\u003e The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,\u003cbr\u003e while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part\u003cbr\u003e covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of\u003cbr\u003e protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.\u003cbr\u003e \u003cbr\u003e With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Wiley-VCH\u003c\/p\u003e \u003cp\u003ePublication Date: 2012-10-15\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003e ISBN-10: 9783527330157\u003c\/p\u003e \u003cp\u003eISBN-13: 9783527330157\u003c\/p\u003e \u003cp\u003eDOI: \u003c\/p\u003e \u003cp\u003eDimensions: 246.40cm x174.00cm\u003c\/p\u003e \u003cp\u003ePages: 256\u003c\/p\u003e ","brand":"Wiley-VCH","offers":[{"title":"Default Title","offer_id":44314935558284,"sku":"9783527330157","price":166.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783527330157_30198629-bc4b-4269-93ab-1859e53448f3.jpg?v=1755358459","url":"https:\/\/lateknightbooks.com\/products\/9783527330157","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}