Facilitate milder, simpler reactions in organic synthesis with this cutting-edge family of building blocks

Donor-Accepted Cyclopropanes, or DACs, have attracted a resurgence of interest from organic chemists in recent decades for their role in facilitating various reactions such as cycloadditions, annulations, ring-opening and enantioselective transformations. The structural arrangement of DACs leads to milder, simpler reaction conditions, which have made them indispensable for a range of fundamentally and industrially important processes.

Donor-Acceptor Cyclopropanes in Organic Synthesis covers comprehensively the chemistry and applications of this compound class. The result is an invaluable guide for any researcher looking to bring DACs to bear in their own areas of research or development.

Readers will also find:

• A brief introduction of the history and reactivity of DACs
• Detailed discussion of reactions including Lewis acid-catalyzed cycloadditions, metal-free activation, asymmetric transformations, organocatalysis, and many more
• Application of DACs in natural product synthesis and pharmaceutical/agrochemical research

Donor-Acceptor Cyclopropanes in Organic Synthesis is ideal for organic chemists, experts in catalysis, pharmaceutical researchers, and any other scientists interested in facilitating milder, simpler reactions.

Prabal Banerjee is an Associate Professor in the Department of Chemistry at the Indian Institution of Technology Ropar (IIT Ropar), Bara Phool, India. He obtained his PhD from National Chemical Laboratory (NCL) under the supervision of Prof. Ganesh Pandey (Pune) and worked with Prof. Gais at RWTH Aachen (Germany) as DFG postdoctoral fellow from 2005 to 2007. He then moved to Purdue University (USA), where he worked with Prof. Fuchs before joining IIT Ropar as an assistant professor in 2010. He was promoted to associate professor in 2016. He has extensive research experience in pericyclic reactions with particular emphasis on cycloaddition reactions, asymmetric catalysis, and synthesis of pharmaceutically important heterocyclic compounds.

Akkattu T. Biju is a Professor in the Department of Organic Chemistry at the Indian Institute of Science, Bangalore, India, since 2023. He received his PhD in 2006 under the guidance of Dr. Vijay Nair at the CSIR-NIIST (formerly RRL), Trivandrum, India. Subsequently, he was a post-doctoral fellow with Prof. Tien-Yau Luh at National Taiwan University and an Alexander von Humboldt-Fellow with Prof. Frank Glorius at WWU Münster (Germany). In 2011, he began his independent research career at CSIR-NCL (Pune), and became an Associate Professor in the Department of Organic Chemistry at the Indian Institute of Science, Bangalore (India) in 2017. His research focuses on the development of transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions using aryne chemistry and NHC organocatalysis, and their application in organic synthesis. He is the Editor of the Journal of Heterocyclic Chemistry (Wiley), and a member of the Advisory Board of Organic Chemistry Frontiers (RSC) and Asian Journal of Organic Chemistry (Wiley).