{"product_id":"9783527353606","title":"Targeting Protein-Protein Interactions for Drug Discovery","description":"\u003ch1\u003eTargeting Protein-Protein Interactions for Drug Discovery\u003c\/h1\u003e\u003ch3\u003eJian Zhang\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Pharmacology\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003e\u003cb\u003eUp-to-date reference surveying the latest advances in the structural understanding of protein-protein interactions and developments in drug discovery and therapeutics\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eTargeting Protein–Protein Interactions for Drug Discovery\u003c\/i\u003e provides a systematic and comprehensive overview of protein-protein interactions (PPIs), reviewing foundational concepts, advanced methodologies, and emerging therapeutic strategies, reflecting the multidisciplinary nature of PPI research. \u003c\/p\u003e\n\u003cp\u003eThis book discusses computational methods for predicting PPI structures, with a special emphasis on protein docking and deep learning-based approaches, diverse chemical scaffolds for PPI modulation, including foldamers as inhibitors of aberrant PPIs and sulfonyl-γ-AApeptides as novel modulators, and the development and application of stapled peptides as modulators of intracellular PPIs, offering enhanced stability, binding affinity, and cellular permeability. \u003c\/p\u003e\n\u003cp\u003eReaders will also find information on cyclic peptides, focusing on their unique conformational stabilization and therapeutic potential across a range of diseases, small molecule inhibitors targeting BCL-family proteins, revealing their potential in cancer therapy, molecular glues as activators for PPIs, categorized into degraders, stabilizers, and inhibitors based on their biological effects, and the targeting of the APC–Asef interaction for drug discovery in colorectal cancer therapy, offering a case study of specificity and clinical relevance. \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eTargeting Protein–Protein Interactions for Drug Discovery\u003c\/i\u003e explores sample topics including: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eChallenges and strategies of drug discovery targeting PPIs, including high-throughput screening and structure-based drug design\u003c\/li\u003e \u003cli\u003eFluorescence resonance energy transfer (FRET) technology, a powerful tool for real-time analysis of molecular interactions in live cells\u003c\/li\u003e \u003cli\u003eUtility of mass spectrometry (MS) for large-scale mapping of PPI networks with high sensitivity and resolution\u003c\/li\u003e \u003cli\u003eProximity ligation assays (PLA) for detecting PPIs in situ, emphasizing spatial precision and adaptability for multiplexed detection\u003c\/li\u003e \u003cli\u003eApplication of surface plasmon resonance (SPR) for characterizing PPI specificity, affinity, and kinetics\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eExploring both classical and novel approaches to PPI characterization and modulation, \u003ci\u003eTargeting Protein–Protein Interactions for Drug Discovery\u003c\/i\u003e offers a comprehensive reference for researchers aiming to unlock the therapeutic potential of PPIs along with educators and students engaged in the study of cellular mechanisms, drug discovery, and biotechnology.\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv\u003e  \u003cp\u003e\u003ci\u003e\u003cb\u003eJian Zhang\u003c\/b\u003e is a Distinguished Professor and Doctoral Supervisor at School of Medicine, Shanghai Jiao Tong University, China. He is also the Director of the Medicinal Bioinformatics Center. His fields of research include first-in-class drug design and chemical biology, mainly pertaining to protein-protein interactions and allostery and their application in drug discovery. He received a BM degree in Pharmacology from Peking University and a PhD from Shanghai Institute of Materia Medica, Chinese Academy of Sciences.\u003c\/i\u003e \u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e11 May 2026\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eWiley\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eWiley-VCH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783527353606\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003eHardback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e432\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWeight (oz): \u003c\/td\u003e\n\u003ctd\u003e24.0\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":44315506311308,"sku":"9783527353606","price":161.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783527353606.jpg?v=1780596413","url":"https:\/\/lateknightbooks.com\/products\/9783527353606","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}