{"product_id":"9783540660026","title":"Current Topics in Microbiology and Immunology: Transduction of BCR Signals from the Cell Membrane to the Nucleus","description":"\u003ch1\u003eCurrent Topics in Microbiology and Immunology: Transduction of BCR Signals from the Cell Membrane to the Nucleus\u003c\/h1\u003e \u003ch2\u003eJustement, Louis B.; Siminovitch, Katherine A.\u003c\/h2\u003e \u003cp\u003eProper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 1999-08-19\u003c\/p\u003e \u003cp\u003eFormat: Hardcover\u003c\/p\u003e \u003cp\u003eISBN-13: 9783540660026\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-57066-7\u003c\/p\u003e \u003cp\u003eDimensions: 235cm x155cm\u003c\/p\u003e \u003cp\u003ePages: 267\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":46311647314060,"sku":"9783540660026","price":98.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783540660026.jpg?v=1771509539","url":"https:\/\/lateknightbooks.com\/products\/9783540660026","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}