This book constitutes the refereed proceedings of the 15th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2009, held in York, UK, in March 2009, as part of ETAPS 2009, the European Joint Conferences on Theory and Practice of Software. The 27 full papers and 8 tool demonstrations included in the volume were thoroughly reviewed and selected from 131 submissions. The papers are organized in topical sections on Model Checking, Tools, Verification of Concurrent Programs, Parametric Analysis, Program Analysis, and Hybrid Systems.