Topics in Current Genetics: From Microbes to Man

Tamás, Markus J.; Martinoia, Enrico

One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

Details

Published by: Springer

Publication Date: 2010-02-12

Format: Paperback

ISBN-13: 9783642060625

DOI: 10.1007/b98249

Dimensions: 235cm x155cm

Pages: 509