{"product_id":"9783642260766","title":"Death Receptors and Cognate Ligands in Cancer","description":"\u003ch3\u003eResults and Problems in Cell Differentiation\u003c\/h3\u003e\u003ch1\u003eDeath Receptors and Cognate Ligands in Cancer\u003c\/h1\u003e\u003ch3\u003eHolger Kalthoff\u003c\/h3\u003e\u003cdiv\u003e\u003cb\u003eMedical \/ Oncology \/ General\u003c\/b\u003e\u003c\/div\u003e\u003cbr\u003e\u003cdiv\u003e\n\u003cp\u003eDeath receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events.\u003c\/p\u003e\r\n\u003cp\u003eBesides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells.\u003c\/p\u003e\r\n\u003cp\u003eThis book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.\u003c\/p\u003e\n\u003c\/div\u003e\u003cbr\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublication Date: \u003c\/td\u003e\n\u003ctd\u003e14 March 2012\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePublisher: \u003c\/td\u003e\n\u003ctd\u003eSpringer Berlin Heidelberg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImprint: \u003c\/td\u003e\n\u003ctd\u003eSpringer\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eISBN-13: \u003c\/td\u003e\n\u003ctd\u003e9783642260766\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFormat: \u003c\/td\u003e\n\u003ctd\u003ePaperback \/ softback\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePage Count: \u003c\/td\u003e\n\u003ctd\u003e280\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":51213608157324,"sku":"9783642260766","price":197.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642260766.jpg?v=1782990137","url":"https:\/\/lateknightbooks.com\/products\/9783642260766","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}