Research and Perspectives in Alzheimer's Disease

Morimoto, Richard I.; Christen, Yves

The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Details

Published by: Springer

Publication Date: 2012-12-12

Format: Hardcover

ISBN-13: 9783642279270

DOI: 10.1007/978-3-642-27928-7

Dimensions: 235cm x155cm

Pages: 136