This book constitutes the thoroughly refereed post-conference proceedings of the Third International Workshop on Computational and Clinical Applications in Abdominal Imaging, held in conjunction with MICCAI 2011, in Toronto, Canada, on September 18, 2011. The 33 revised full papers presented were carefully reviewed and selected from 40 submissions. The papers are organized in topical sections on virtual colonoscopy and CAD, abdominal intervention, and computational abdominal anatomy.