Springer Theses

Ouldridge, Thomas E.

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

Details

Published by: Springer

Publication Date: 2012-07-07

Format: Hardcover

ISBN-13: 9783642305160

DOI: 10.1007/978-3-642-30517-7

Dimensions: 235cm x155cm

Pages: 176