Springer Theses: Synthesis and Biological Evaluation

Duffy, Colm

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

Details

Published by: Springer

Publication Date: 2014-02-22

Format: Paperback

ISBN-13: 9783642438929

DOI: 10.1007/978-3-642-24632-6

Dimensions: 235cm x155cm

Pages: 130