Current Topics in Microbiology and Immunology

Nair, G. Balakrish; Takeda, Yoshifumi

The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oralcholera vaccines to stop the spread of cholera outbreaks.

Details

Published by: Springer

Publication Date: 2014-07-03

Format: Hardcover

ISBN-13: 9783642554032

DOI: 10.1007/978-3-642-55404-9

Dimensions: 235cm x155cm

Pages: 263