Research and Perspectives in Alzheimer's Disease

Hyman, Bradley T.; Demonet, Jean-Francois

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

Details

Published by: Springer

Publication Date: 2014-04-15

Format: Paperback

ISBN-13: 9783642639272

DOI: 10.1007/978-3-642-59300-0

Dimensions: 235cm x155cm

Pages: 180