{"product_id":"9783642680250","title":"Retinoids: Advances in Basic Research and Therapy","description":"\u003ch1\u003eRetinoids: Advances in Basic Research and Therapy\u003c\/h1\u003e \u003ch2\u003eOrfanos, C.E.; Braun-Falco, O.; Farber, E.M.; Grupper, C.; Polano, M.K.; Schuppli, R.\u003c\/h2\u003e \u003cp\u003eWith the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre­ sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio­ transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2011-12-10\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003eISBN-13: 9783642680250\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-642-68023-6\u003c\/p\u003e \u003cp\u003eDimensions: 244.0cm x170.0cm\u003c\/p\u003e \u003cp\u003ePages: 530.0\u003c\/p\u003e ","brand":"Springer Berlin Heidelberg","offers":[{"title":"Default Title","offer_id":44448542785676,"sku":"9783642680250","price":152.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783642680250.jpg?v=1756870984","url":"https:\/\/lateknightbooks.com\/products\/9783642680250","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}