Innovation represents a source of growth and profitability for firms in today's globalizing competitive environment. In particular, radical innovations are gaining in importance for large established companies as they can be considered a source of organizational rejuvenation. Some large companies organize for radical innovations by establishing dedicated organizational structures. The present study provides a common basis for these activities drawing upon research in the field of radical innovation management and corporate entrepreneurship, which are integrated in a new definitional framework of “New Business Creation” (NBC). In six in-depth case studies and a cross-case analysis, Theo Fowinkel explores the management of human resources in NBC as the commitment, enthusiasm, and self-motivation of employees significantly affects the development of radical innovation.