BestMasters: Sequential Treatment Allocation Based on Markov Decision Problems

Ondra, Thomas

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

Details

Published by: Springer Spektrum

Publication Date: 2014-12-18

Format: Paperback

ISBN-13: 9783658083434

DOI: 10.1007/978-3-658-08344-1

Dimensions: 210cm x148cm

Pages: 102