{"product_id":"9783662224960","title":"The Human T-Cell Receptor Repertoire and Transplantation","description":"\u003ch1\u003eThe Human T-Cell Receptor Repertoire and Transplantation\u003c\/h1\u003e \u003ch2\u003eElsen, Peter van den\u003c\/h2\u003e \u003cp\u003ethese analyses it became clear that the MHC class I molecule com­ prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec­ tron-dense material in the groove. This material was subsequently iden­ 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu­ tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep­ tion of the DR a-chain, all other MHC class II a and 13 chains are poly­ morphic.\u003c\/p\u003e \u003ch3\u003eDetails\u003c\/h3\u003e \u003cp\u003ePublished by: Springer\u003c\/p\u003e \u003cp\u003ePublication Date: 2013-11-13\u003c\/p\u003e \u003cp\u003eFormat: Paperback\u003c\/p\u003e \u003cp\u003e ISBN-10: 9783662224960\u003c\/p\u003e \u003cp\u003eISBN-13: 9783662224960\u003c\/p\u003e \u003cp\u003eDOI: 10.1007\/978-3-662-22494-6\u003c\/p\u003e \u003cp\u003eDimensions: 254cm x178cm\u003c\/p\u003e \u003cp\u003ePages: 173\u003c\/p\u003e ","brand":"Springer","offers":[{"title":"Default Title","offer_id":44341124006028,"sku":"9783662224960","price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0710\/9545\/1788\/files\/9783662224960_c5f204f2-96e8-4411-a151-2cc00af86bf8.jpg?v=1755057972","url":"https:\/\/lateknightbooks.com\/products\/9783662224960","provider":"Late Knight Books and Services, LLC","version":"1.0","type":"link"}