Vaccine Analysis: Strategies, Principles, and Control

Nunnally, Brian K.; Turula, Vincent E.; Sitrin, Robert D.

This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities.

Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.

Details

Published by: Springer

Publication Date: 2014-12-09

Format: Hardcover

ISBN-13: 9783662450239

DOI: 10.1007/978-3-662-45024-6

Dimensions: 235cm x155cm

Pages: 665