Neocarzinostatin: The Past, Present, and Future of Anticancer Drug

Maeda, Hiroshi; Edo, Kiyoto; Ishida, Nakao

The 20th century has witnessed the great benefits of the development of antibi­ otics, which became a reality after World War IL More than 50 years ago I witnessed the miraculous therapeutic power of penicillin, when I was a student at the Tohoku University Medical School's Department of Bacteriology in Sendai, Japan. The late Dr. Kondo was a graduate student in the department at that time and developed the first crude penicillin preparation in Japan which was applied with dramatic results in two patients. Although there was patient-family consent at that time, ethics committees, randomization. mutagenesis tests, distribution studies, purity-criteria, and phar­ macokinetics were not yet in existence. Today, regulatory procedures have com­ plicated the whole drug-approval process. For example, any new antibiotics that have been proven effective in laboratory studies against gram-negative bacteria, as might exist in deadly plague bacteria, must still undergo a long and enormously costly regulatory process before they can be introduced to benefit society, and before government insurance can be applied.

Details

Published by: Springer

Publication Date: 2013-10-03

Format: Paperback

ISBN-13: 9784431669166

DOI: 10.1007/978-4-431-66914-2

Dimensions: 229cm x152cm

Pages: 287