Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis

Kale, Avinash

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria.  As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. 

Details

Published by: Springer

Publication Date: 2019-11-26

Format: Hardcover

ISBN-13: 9789811374494

DOI: 10.1007/978-981-13-7450-0

Dimensions: 235.0cm x155.0cm

Pages: 101.0