The book addresses the prevalent digital transformation and focuses on its significant disruption in healthcare. In light of the distinctive characteristics and evolution of the Chinese healthcare industry, private multi-sided platform (MSP) companies emerge to offer novel values and explore the industry value chain. Drawing on the management and economics literature of MSPs, this book examines the selected Chinese MSPs and compares them with the counterpart MSPs in the U.S. This analysis highlights how the unfolding healthcare disruption is valuable for both scholars and practitioners to understand the trends and to take effective actions. “Disruptive Innovation through Digital Transformation: Multi-Sided Platforms of E-Health in China” provides readers in the developing and developed countries with insights on how to approach the current multi-sided platform and to resolve the current problems to better serve customers and patients in the healthcare market.