This two-volume set, constitutes the revised selected papers of the 16th International Symposium on Intelligence Computation and Applications, ISICA 2025, held in Guangzhou, China, during November 15–16, 2025.

The 63 full papers included in these proceedings were carefully reviewed and selected from178 submissions. They were organized in the following topical sections: 

Part I : Frontiers of Evolutionary Intelligent Optimization Algorithms; Intelligent Systems and Detection Technology.
Part II : Exploration of Computer Vision; Machine Learning and Its Applications; AI Empowering Education and Design Innovation.