The volume constitutes the refereed proceedings of the 15th International Conference on Advances in Brain Inspired Cognitive Systems, BICS 2025, held in Suzhou, China, during November 28–30, 2025.

The 37 full papers and 5 short paper included in this book were carefully reviewed and selected from 69 submissions. They were organized in topical sections as follows: Neuro-Cognitive Modelling; -Inspired Medical Imaging and Analysis; Multimodal Perception and Interaction; Adaptive and Evolutionary Optimization.