This book highlights recent theoretical and experimental advancement in Condensed Matter and High Energy Physics using AI and ML techniques to discover new phases of matter, such as crystalline and non-crystalline phases, unconventional superconducting phases, electronic and magnetic phases, and quark-gluon plasma phases, as well as neutrinos and dark matter. This book is a timely contribution to Condensed Matter and High Energy Physics, as well as a useful resource for beginners and advanced researchers who want to use AI & ML tools in Condensed Matter and High Energy Physics.