This book provides a comprehensive, theoretically grounded framework for the most profound challenge facing medical education in the twenty-first century: the integration of Artificial Intelligence (AI). It bridges the gap between visionary works on the future of AI in clinical practice and the practical, on-the-ground needs of medical educators, providing a comprehensive, end-to-end roadmap. This book proposes a systematic journey through the entire educational continuum—from basic sciences to clinical rotations and assessment—all viewed through the single, coherent lens of its new model. This book serves as an essential resource for various audiences. For academic leaders and deans, this book provides a clear, strategic, and evidence-based roadmap to guide their institution's transformation, turning a daunting challenge into a manageable, structured process. For medical educators and faculty, it offers practical, actionable strategies and conceptual tools to update their courses, teaching methods, and assessments, empowering them in their daily work. For researchers and graduate students, it serves as a foundational theoretical text that defines the key challenges and opportunities in the field, providing a launchpad for a new generation of scholarly inquiry. Ultimately, this book serves as a guide for cultivating physicians whose uniquely human capacities for wisdom, empathy, and judgment are not replaced, but amplified and liberated by their partnership with artificial intelligence.

Fei Liu is affiliated with the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Dr. Liu’s scholarly work bridges technical AI development, clinical application, and educational implementation. His representative publications include studies on generative foundation models for medicine, multimodal clinical data integration, and AI-supported medical learning, with work appearing in journals such as Cell, Nature Medicine, Nature Genetics, Nature Reviews Cancer, Cell Reports Medicine, Computers & Education, and Smart Learning Environments. 

Xunming Ji is President of the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, and Academician of the Chinese Academy of Engineering. His work spans clinical medicine, brain science, and medical innovation, and he has played an important leadership role in advancing medical education, research, and institutional development.