The book presents a detailed overview of core-shell nanoparticles for stimuli-responsive drug delivery, combining fundamental principles with recent innovations. It explains how these nanostructures are designed to respond to diverse triggers like pH, temperature, enzymes, redox, magnetic fields, and light, enabling precise therapeutic release. By integrating design, synthesis, and characterization, the volume highlights their role in advancing smart nanocarriers.

The background lies in the limitations of conventional therapies, which often suffer from poor bioavailability, systemic toxicity, and lack of site-specific action. Core-shell nanoparticles overcome these challenges by enhancing encapsulation, stability, and targeted release. Their multifunctionality and biocompatibility make them promising for cancer, infections, inflammation, and neurological disorders, aligning with the broader evolution of nanomedicine and biomaterials research.

Chapters are organized into five parts: fundamentals of nanoparticle design and functionalization; material-based systems such as polymeric, silica, metallic, lipid, and DNA/peptide carriers; stimuli-responsive mechanisms; biocompatibility, toxicity, and pharmacokinetics; and translation toward commercialization. Each section blends theoretical insights with application-oriented perspectives, supported by contributions from international experts in nanotechnology, pharmaceutics, and biomedical engineering.

The audience includes researchers, pharmaceutical scientists, clinicians, and graduate students across disciplines such as nanotechnology, pharmaceutics, biotechnology, materials science, and biomedical engineering. Apart from this healthcare professionals, industry specialists, and regulatory policymakers will also benefit from its practical insights on safety, efficacy, and clinical translation.

Dr. Raj Kumar serves as Assistant Professor in the School of Health Sciences and Technology at UPES University, Dehradun, India. He holds an M.Sc. in Organic Chemistry from Osmania University and a Ph.D. in Chemistry from IIT Mandi. With over 14 years of academic and research experience, his work focuses on nanocarriers for targeted drug delivery in gastric cancer, inflammatory bowel disease, contraception, and neural tissue engineering. His projects have been supported by leading agencies such as UGC, SERB, Israel’s Planning and Budgeting Committee, and the NIH in the United States. Dr. Kumar has published more than 77 papers and book chapters, with over 3,000 citations and an h-index of 33. He holds patents on innovative nanocarrier technologies, including solvent–antisolvent interaction methods and co-delivery systems for siRNA and chemotherapeutics. His achievements have earned him fellowships from UGC, DST, and Israel’s PBC, and he participated in the 71st Lindau Nobel Laureates Meeting in 2021. His current research interests center on nano-biomaterials for drug delivery and tissue engineering.

Dr. Ajeet Kaushik is Assistant Professor of Chemistry in the Department of Environmental Engineering at Florida Polytechnic University, USA, where he leads the NanoBioTech Lab. His research integrates green chemistry, electrochemical sensors, nanomedicine, and IoT-enabled diagnostics. He earned his Ph.D. in Chemistry through a joint program at the National Physical Laboratory and Jamia Millia Islamia, New Delhi, followed by postdoctoral work in Ireland, South Korea, and the United States. Dr. Kaushik has authored over 320 peer-reviewed publications, edited 12 books, and holds three patents. His work is consistently ranked among the top 2% of global scientists, with major contributions to sensors, drug delivery, and biomedical nanotechnology. He mentors Ph.D. students internationally, collaborates widely across continents, and is active in scientific societies and editorial boards. His honors include Fulbright Specialist recognition and the RSC Outstanding Reviewer Award.

Dr. Yogendra Kumar Mishra is Professor (WSR) at the Mads Clausen Institute, University of Southern Denmark, where he leads the Smart Materials Group within SDU NanoSYD. He earned his Ph.D. in Physics from Jawaharlal Nehru University/Inter-University Accelerator Centre, New Delhi, in 2008, and completed his habilitation in Materials Science at Kiel University in 2015. Previously, he led the 3D Nanomaterials Group at Kiel University as an Alexander von Humboldt Fellow. Dr. Mishra is internationally recognized for pioneering flame-based synthesis of zinc oxide tetrapods and developing 3D hybrid networks. His research spans smart materials, hybrid composites, energy materials, sensors, biomaterials, catalysis, water purification, plasmonics, and photonics. He has authored over 300 publications, with more than 18,000 citations and an h-index of 68. Beyond research, he serves on editorial boards, reviews extensively for scientific journals, evaluates grants, and contributes to international collaborations and committees.