This 2nd edition offers a comprehensive exploration of anxiety disorders, covering genetic, molecular, and neural mechanisms as well as clinical features and therapeutic strategies. It highlights the transformative potential of pharmacogenetics and gene–environment interactions in advancing precision medicine, alongside detailed analysis of molecular and cellular factors such as synaptic dysfunction, neuroinflammation, and the gut–brain axis.

The book also presents cutting-edge insights into neural circuits, featuring advances in brain imaging and brain-based models that enhance diagnosis and treatment. Clinical perspectives emphasize the need for objective biological markers, address cognitive biases, and focus on under-recognized anxiety presentations across diverse populations, including childhood, late life, and pregnancy. The critical issue of suicide risk is thoughtfully examined. Finally, the book reviews a wide range of therapeutic approaches, from established pharmacotherapy and psychotherapy to innovative treatments like psychedelics, brain stimulation, and digital interventions such as virtual reality.

Serving as a vital resource for clinicians, researchers, and mental health professionals, this book combines traditional and novel paradigms to deepen understanding of anxiety disorders and support the development of more personalized, effective interventions.

Yong-Ku Kim, MD, PhD is a Professor of Psychiatry at College of Medicine, Korea University. He received a MD degree from College of Medicine, Korea University in 1987 and a PHD in psychiatry from Korea University in 1998. Dr. Kim is recognized globally for his extensive research in biological psychiatry and neuropsychopharmacology. His research focuses heavily on understanding the biological and structural mechanisms behind psychiatric conditions. His main areas of study include Biological Psychiatry, Neuropsychopharmacology and Immunopsychiatry, and Pathophysiology and Biomarkers of Anxiety and Depression, Suicide and Schizophrenia. He serves as an Associate Editor for Progress in Neuro-psychopharmacology and Biological Psychiatry (PNPBP). He has authored three hundreds of peer-reviewed international articles and also twenty edited many definitive textbooks published by Springer Nature and Elsevier.He serves as a full member of the prestigious Korean Academy of Medicine. Elsevier and Stanford University have consistently listed him among top 2% most-cited scientists in the world since 2020.